Endocrine Abstracts

Introduction: Pheochromocytomas(PCC) and paragangliomas(PGGLs) are rare neuroendocrine tumors. Management is very complex, this is why physicians involved in the management of these patients need to take into account not only clinical aspects but also genetics of these tumors. We present a group of patients diagnosed of metastatic PGG or PCC, their characteristics and long term follow-up.Methods and design: Descriptive and unicentric study that includes ...

Introduction: Hypophosphatasia (HPP) is an inherited disease, characterized by a non-tissue-specific alkaline phosphatase deficiency that leads to abnormal mineralization of bone tissue, which promotes fragility fractures. A defective muscle status could have important clinical repercussions on fracture risk. The aim of this work was to evaluate the relationship between bone and muscle compartment.Material and Methods: Observational cross-sectional study...

Introduction: Dulaglutide (Trulicity®) is a long-acting GLP-1 agonist that received US Food and Drug Administration (FDA) approval in 2014. Dulaglutide is a large sized molecule, which limits its renal clearance. This allows for once weekly dosing; which might improve patient compliance significantly. Extensive Phase III study data have been published with regard to dulaglutide, much of which was part of the AWARD studies, which provide evidence for its use in ...

Diabetes and acute hyperglycemia are known to increase stroke volume and disability in stroke patients, and deliver worse outcomes after reperfusion therapies. Chronic glycemic status has recently been linked to stroke functional outcome, but its impact on long term prognosis of stroke has rarely been studied. We conducted a study to investigate the impact of glycosylated hemoglobin (HbA1c) levels on functional outcome 1 year after stroke.Methods: Patien...

Background and objective: The incidence of differentiated thyroid carcinoma (DTC) is increasing worldwide. Due to a increased use of improved radiological techniques, especially ultrasound. This study aims to analyze histological characteristics of DTC diagnosed in our hospital in the last fifteen years.Patients and methods: It is a restrospective descriptive study. We have included all operated patients in our center between 2001 and 2015 with a final b...

Introduction: The association of bullous pemphigoid (BP) with the use of dipeptidyl-peptidase 4 (DPP-4) inhibitors among patients with diabetes has recently emerged. The risk of developing BP during treatment with new DPP-4 inhibitor agents like linagliptin is yet to be established. The clinical features and the prognostic outcomes of patients with DPP-4 inhibitor-associated BP are yet to be established.Objective: To report a case of BP on a patient with...

GH secreting adenomas could be associated with clinical acromegaly with or without hyperprolactinemia, being rare cases of non functioning adenomas. They correspond a 25–30%of pituitary adenomas, generaly presented as macroadenoma.Frequently, they have another hormones production, often prolactin and TSH. Almost 75% of cases are macroadenomas. A 48-year-old Caucasian patient admitted complaining of facial craniofacial alterations, polyarthralgia, holocranial headache and ...

Thyroid hypophyseal adenomas correspond to about 0.5 to 1% of pituitary adenomas. Tumor hypersecretion of TSH may also be present in plurihormonal adenomas that simultaneously secrete growth hormone and/or prolactin or FSH and LH glycoprotein hormones. A 37-year-old patient complaining of ears, hands, feet and face growth for 1 year. He reported amenorrhea for 04 years, sweating and joint pains. Associated comorbidities: Systemic arterial hypertension for 4 years in the use of...

Introduction: Klinefelter syndrome (KS) is the most common congenital abnormality causing primary hypogonadism. KS has a tendency for hypercoagulability.Case report: A 48 year old man diagnosed as having KS during the sterility test was admitted to our hospital emergency department after suffering a syncopal episode at work. He complained of difficulty breathing during the last two weeks and he was receiving bronchodilator therapy. He had suffered deep v...

Posterior reversible encephalopathy syndrome (PRES) is a neurological disorder characterized by varied neurological symptoms. There are two leading theories regarding the pathophysiology: hypertension crisis and endothelial dysfunction.Case reportWe report the case of a 42-year-old patient with history of hypertension. She presented to the emergency department with headache and bilateral loss of vision. She described one previous e...